In this talk we will focus on two-fluid formulations where the fluids are assumed to be compressible and viscosity effects are included in the momentum equations. In the introduction we try to motivate for the study of this model: why can such models be a useful tool for engineers. Then we will narrow the scope and describe a two-fluid model for cell migration. This model can be understood as a generalization of more classical Keller-Segel type of models for cell migration due to random motion and chemotaxis. The model takes the form of a (weakly) compressible two-fluid model with non-conservative pressure terms and interaction terms that play a key role in the momentum equations. The link to Keller-Segel type of models is established by imposing simplifying assumptions and making a specific choice of the interaction term. Existence of global regular solutions for the proposed model for cell migration is then obtained for sufficiently small and regular initial data. The central ingredient in the proof is a basic energy estimate which is combined with certain higher order estimates of cell mass, water mass, and mass of the chemical agent. We also include some examples of numerical solutions of the proposed model that demonstrate pattern formation properties characteristic for Keller-Segel type of models. Sensitivity to different parameters is explored. Finally, we also show some numerical results for a 2D version of a similar model.